With the proper template (and there is one for nonprofits included with Access), it's not too difficult for someone with a modicum of computer savvy to put together a program to handle the basics of fundraising using either Excel or Access. However, remember that the fundraising world is not static, and neither should be your fundraising program—continuing maintenance could become a drain on your time and resources.
In our opinion, there are two situations in which using Access or Excel (or similar products) might make sense.